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Search Term: cancer

Technologies


Peptides targeting EGFL7, a critical player in angiogenesis
Background:Epidermal growth factor-like 7 (EGFL7) is an endothelial cell secreted protein whose expression is restricted to actively remodeling vascular endothelium. It is critical for vascular tube formation during angiogenesis through localizing to the extracellular matrix (ECM) at the basal surface of endothelial cells and promoting endothelial ...
Kinetic Deconvolution Optical Reconstruction Algorithm (KDOR) for retrieving multiregional hemodynamic parameters from optical measurements
Background:Dynamic contrast enhanced (DCE) methods can be used in biomedical optics to measure the kinetic properties of tissue, such as blood flow, blood volume, leakage and receptor density. Similar to DCE methods in computed tomography, magnetic resonance imaging or positron emission tomography, the injection of an optical dye is required. Conve...
Anti-Infective Efficacy of Histatin-Related Peptide DB2121
Background:In order to maximize resources, biological systems are designed to generate multifunction protein units that serve different roles depending upon need and context. In particular, there are several families of proteins that have emerged with both antimicrobial properties, as well as bi-activity to promote wound closure and healing. Fungal...
New Powerful Tool for Monitoring of Kinase Activity
Background:In the cellular signalling network, many enzymes and receptors are activated (phosphorylated) or deactivated (dephosphorylated) by protein kinases. As a result of these modifications, the function of the protein may change. Many disease processes including cancer, heart disease, diabetes, autoimmune and chronic inflammatory diseases are ...
Ghrelin Analogues as Molecular Imaging Probes
Background: Human Growth Hormone Secretagogue Receptor (GHSR), a member of the G Protein-Coupled Receptors (GPCR) family, is mainly expressed in the hypothalamus, pituitary cells and a number of peripheral tissues. Expression of the GHSR has been reported in various types of tumors, including breast carcinomas, prostate cancer cell lines, ovarian t...
Establishment of Serum Tumor Marker in Mouse Prostate Cancer Model Studies
Background: Prostate cancer is the most common cancer in adult men in North America. A number of genetically engineered (GE) mouse models exist for basic and preclinical prostate cancer research. However, until now, no in vivo serum biomarker has been available to better understand, evaluate and demonstrate the efficacy of new therapies or drugs. I...
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