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Search Term: therapeutics/intervention

Technologies


Selective Brain Cooling Technology
BackgroundBrain cooling (hypothermia) has been shown to prevent brain injury (neuroprotection) from stroke, brain trauma and cardiac arrest in both animal models and patient studies. Currently, the main hurdles in the clinical application of hypothermia are: 1) most brain cooling methods also cool down the rest of the body with its associated compl...
The Desired Sensation Level Multi-stage [i/o] Algorithm
The Desired Sensation Level: DSL [i/o] algorithm was released to manufacturers in the late 1990s in the form of a dynamic loadable/linked library (DLL). We appreciate your support and want you to know that the money that we have received from manufacturers in the form of license fees for the DLL is put back into research, development and technical ...
miR-195 Antagomir Treatment of Sepsis
Background: MicroRNAs (miRNAs) are small non-coding RNA molecules encoded by eukaryotic nuclear DNA, on average 22 nucleotides long, that function in transcriptional and post-transcriptional regulation of gene expression via base-pairing with complementary sequences within mRNA molecules, usually resulting in gene silencing via translational repres...
Peptides targeting EGFL7, a critical player in angiogenesis
Background:Epidermal growth factor-like 7 (EGFL7) is an endothelial cell secreted protein whose expression is restricted to actively remodeling vascular endothelium. It is critical for vascular tube formation during angiogenesis through localizing to the extracellular matrix (ECM) at the basal surface of endothelial cells and promoting endothelial ...
Bone Marrow Derived Cells That Stimulate Pancreatic Regeneration in Type II Diabetes
Background:Diabetes affects over 18M Americans with almost 90% of these being attributed to environmental factors and lifestyle decisions. In the United States and Europe alone, the number of type II diabetes patients is expected to rise to ~41.5M by 2012. In contrast to type I diabetes, in type II diabetes the individual genetics of pancreas funct...
Anti-Infective Efficacy of Histatin-Related Peptide DB2121
Background:In order to maximize resources, biological systems are designed to generate multifunction protein units that serve different roles depending upon need and context. In particular, there are several families of proteins that have emerged with both antimicrobial properties, as well as bi-activity to promote wound closure and healing. Fungal...
Target, Compounds, and Discovery System for Limiting Scarring and Promoting Regeneration Following CNS Injury
Background:Spinal cord injury (SCI) is a personally catastrophic event that often results in disability and lifelong institutional care requirements. In the United States and Canada, more than 12,000 spinal cord injuries occur annually and ~275,000 people live with permanent, serious disabilities at an average medical cost of $22,000/person/year. I...
New Powerful Tool for Monitoring of Kinase Activity
Background:In the cellular signalling network, many enzymes and receptors are activated (phosphorylated) or deactivated (dephosphorylated) by protein kinases. As a result of these modifications, the function of the protein may change. Many disease processes including cancer, heart disease, diabetes, autoimmune and chronic inflammatory diseases are ...
Schizophrenia Animal Model
Background: Schizophrenia is a severely debilitating life-long disease with symptoms typically appearing in the early twenties, and consequently, it leaves a tremendous financial burden on patients and the society. Approximately 2.5 million Americans and 1% of the worldwide population (1 out of every 100 people) suffer from schizophrenia. The socia...
Vaccination Rheumatoid Arthritis Therapy
Background:Rheumatoid arthritis affects nearly 1% of the world population. Within the United States, approximately 2.1 million individuals suffer from rheumatoid arthritis. Existing therapies have offered symptomatic relief from inflammation associated with rheumatoid arthritis but have not addressed the root causes of the disease. The current mark...
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