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Kinetic Deconvolution Optical Reconstruction Algorithm (KDOR) for retrieving multiregional hemodynamic parameters from optical measurements

Background:

Dynamic contrast enhanced (DCE) methods can be used in biomedical optics to measure the kinetic properties of tissue, such as blood flow, blood volume, leakage and receptor density. Similar to DCE methods in computed tomography, magnetic resonance imaging or positron emission tomography, the injection of an optical dye is required. Conventionally, optical DCE data is treated like the other modalities, where first a time-series of DCE maps are reconstructed and then kinetic analysis is applied to these images to recover the parameters of interest. However, unlike CT or MRI, optical reconstruction is ill-posed and recovered images are blurry. The blurring of information violates the implicit assumption in the subsequent kinetic analysis, mainly that each voxel represents a single tissue-type. For this reason, few studies involving the kinetic analysis of complex DCE data have been reported.

Description of the Invention:

The kinetic deconvolution optical reconstruction (KDOR) method combines spatial reconstruction and nonparametric kinetic analysis into a single inverse problem, dramatically improving the accuracy and precision of recovered kinetic parameters. The KDOR algorithm provides a powerful framework to system solve for a flexible set of parameters, and can incorporate spatial and spectral priors (hard and soft).

Potential Advantages:

• Improved precision of hemodynamic parameters
• One step mathematical approach
• High spatial and temporal resolution is not required
• Spectral and spatial priors can be easily incorporated into KDOR

Potential Applications:

• Bedside non-invasive optical measurements of cerebral hemodynamics in adults
• Bedside non-invasive assessment of cerebral vascular damage in stroke patients
• Optical tomography of breast cancer
• Optical imaging of the prostate with transrectal probes to improve detection, surveillance and monitoring of treatment response
• Pre-clinical quantitative optical tomography.

Patent Information:

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