Technologies

Attenuation of infection by Staphylococcus aureus

Tech ID: W-20-013

Summary

Researchers at Western University have identified a compound that can inhibit the growth of Staphylococcus aureus, a deadly bacterium that can cause pneumonia and sepsis and is resistant to many antibiotics.

Background

In humans, Staphylococcus aureus may exist as a commensal bacterium or as a pathogen. Data from the United States Centers for Disease Control and Prevention show that approximately one-third of the US population is colonized with S. aureus, and colonization with S. aureus is associated with increased risk of subsequent infection. Infections caused by S. aureus range in severity from relatively minor skin and soft tissue infections through to invasive diseases such as pneumonia, infective endocarditis and osteomyelitis. Strikingly, the magnitude of morbidity and mortality caused by S. aureus is highlighted by reports that, in the US, invasive infections by this bacterium cause more deaths than HIV.

Despite a wealth of knowledge on virulence regulation in S. aureus, there are still outstanding questions to be resolved, as novel mechanisms of virulence regulation are still being discovered, especially with regard to environmental or metabolic cues to which S. aureus responds.

Technology Overview

Researchers at Western University have identified a have discovered a compound that can inhibit the growth of Staphylococcus aureus, a deadly bacterium that can cause pneumonia and sepsis and is resistant to many antibiotics

The compound is already used to treat inflammatory bowel disease and some cancers, but had never been investigated in the context of treating bacterial infections

Benefits and Applications

  • Solution to difficult to treat infections by Staphylococcus aureus or MRSA.
  • Identification of small molecule or targets to attenuate Staphylococcus aureus virulence.
  • Treatment methods for Staphylococcus aureus infections.
  • New class of anti-bacterials

Publications and Media

Chin, D., Goncheva, M.I., Flannagan, R.S. et al. Coagulase-negative staphylococci release a purine analog that inhibits Staphylococcus aureus virulence. Nat Commun 12, 1887 (2021). https://www.nature.com/articles/s41467-021-22175-3

Research News: Fighting infection by harnessing the competitive nature of bacteria

Molecule could beat antibiotic-resistant infections

IP status

Provisional Filing

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Saqib Sachani

Business Development Officer

+1.519.661.2111 x82434

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