Tech ID: TP-W-BI-006
A novel system to modulate the composition of the microbiome
A robust state-of-the-art method to manipulate the microbiome.
Microbial ecosystems are essential for human health and proper development, and disturbances of the ecosystem correlate with a multitude of diseases. A central problem is the lack of tools to selectively control pathogenic species that cause disease, or to otherwise alter or transform the composition of the human or non-human microbiome.
Researchers at Western University have developed a novel state-of-the-art system in combination with enhancements to current gene editing technology to modulate the microbiome. Traditional methods which include antibiotics, phage-based therapy, probiotics and prebiotics are challenged with limitations and exhibit disadvantages. Using the current technology enables one to modulate the microbiome, to eliminate or alter fitness for a bacterium within a biofilm (hard to reach areas) with close to 100% efficiency.
Benefits and Applications
- Alter a single bacterium within a microbiome – eliminate or modulate fitness
- System works efficiently within bacterial biofilms with target and elimination with close to 100% efficiency
- Allows to target bacteria with antibiotic resistance
- Alter microbiome within a human or non-human microbiome
- System may be administered topically, transdermally, sublingually, rectally, vaginally, ocularly, subcutaneous, intramuscularly, intraperitoneally, urethrally, intranasally, by inhalation or orally
- Current system may also be administered directly to site of microbial infection
- Treatment: for example, but not limited to – urinary tract infections, oral cavities, infections associated with implanted prosthetic devices, dental implants, or medical devices, skin infections