Tech ID: TP-W-BI-006
A novel system to modulate the composition of the microbiome
A robust state-of-the-art method to manipulate the microbiome.
Microbial ecosystems are essential for human health and proper development, and disturbances of the ecosystem correlate with a multitude of diseases. A central problem is the lack of tools to selectively control pathogenic species that cause disease, or to otherwise alter or transform the composition of the human or non-human microbiome.
Researchers at Western University have developed a novel state-of-the-art system in combination with enhancements to current gene editing technology to modulate the microbiome. Traditional methods which include antibiotics, phage-based therapy, probiotics and prebiotics are challenged with limitations and exhibit disadvantages. Using the current technology enables one to modulate the microbiome, to eliminate or alter fitness for a bacterium within a biofilm (hard to reach areas) with close to 100% efficiency.
Benefits and Applications
- Alter a single bacterium within a microbiome – eliminate or modulate fitness
- System works efficiently within bacterial biofilms with target and elimination with close to 100% efficiency
- Allows to target bacteria with antibiotic resistance
- Alter microbiome within a human or non-human microbiome
- System may be administered topically, transdermally, sublingually, rectally, vaginally, ocularly, subcutaneous, intramuscularly, intraperitoneally, urethrally, intranasally, by inhalation or orally
- Current system may also be administered directly to site of microbial infection
- Treatment: for example, but not limited to – urinary tract infections, oral cavities, infections associated with implanted prosthetic devices, dental implants, or medical devices, skin infections
Publication in Nature Communications: https://www.nature.com/articles/s41467-019-12448-3
Hamilton, T.A., Pellegrino, G.M., Therrien, J.A., Ham, D.T., Bartlett, P.C., Karas, B.J., Gloor, G.B. and Edgell, D.R. (2019) Efficient inter-species conjugative transfer of a CRISPR nuclease for targeted bacterial killing. Nature Communications 10: 4544
Western News Article on Technology: https://news.westernu.ca/2019/10/work-explores-next-gen-antimicrobial-agents/
Western News Article on CRISPR: https://news.westernu.ca/2019/10/edgell-precision-needed-to-live-up-to-promise/