Technologies

Portable Temperature Regulating Device for Organ Transportation

A portable temperature regulating device that could be integrated to either static cold storage (SCS) or perfusion devices for organs transportation.

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Cell Culture Supplements for Generating Mature, Functional, Stabilized Blood Vessels In Vitro

The difficulty in generating complex functional blood vessels in vitro has been an important limitation to the adoption and application of complex cell based models for functional screening and drug discovery. While the formation of endothelial tubes is well known within the academic literature, the ability to generate integrated vessels that contain vascular endothelial cells, associated smooth muscle cells, and demonstrate vasoreactivity has been elusive.

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Annexin and its Use to Treat Inflammatory Disorders

Sepsis is a complex clinical syndrome resulting from a harmful host immune response to infection characterized by the production of tumor necrosis factor-α (TNF-α), a pro-inflammatory cytokine, which has been shown to be one of the main mediators of cardiovascular dysfunction.

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Ghrelin Analogues as Molecular Imaging Probes

Human Growth Hormone Secretagogue Receptor (GHSR), a member of the G Protein-Coupled Receptors (GPCR) family, is mainly expressed in the hypothalamus, pituitary cells and a number of peripheral tissues.

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Schizophrenia Animal Model

Schizophrenia is a severely debilitating life-long disease with symptoms typically appearing in the early twenties, and consequently, it leaves a tremendous financial burden on patients and the society. Approximately 2.5 million Americans and 1% of the worldwide population (1 out of every 100 people) suffer from schizophrenia.

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EGFR antagonist-mediated prevention of post myocardial infarction ruptures

Cardiovascular disease is a leading cause of death worldwide, claiming the lives of an estimated 17 million people annually. Myocardial infarctions (MI), or heart attacks, are a leading cause of mortality and morbidity. Complications following MI include maladaptive left ventricle (LV) tissue remodeling and cardiac rupture.

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Peptides targeting EGFL7, a critical player in angiogenesis

Epidermal growth factor-like 7 (EGFL7) is an endothelial cell secreted protein whose expression is restricted to actively remodeling vascular endothelium. It is critical for vascular tube formation during angiogenesis through localizing to the extracellular matrix (ECM) at the basal surface of endothelial cells and promoting endothelial cell adhesion. In adults, expression of EGFL7 is detected only at sites of active angiogenesis during wound repair, in the pregnant uterus and in tumors.

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Food-Grade Bacteria Species to Detoxify and Remove Heavy Metals from Humans

There are many heavy metals in our environment, both naturally and from pollution. The term “heavy metal” applies to a group of metals with similar chemical properties. Some of these, including copper, iron and zinc, play important roles in our bodies, while others can have toxic effects.

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miR-195 Antagomir Treatment of Sepsis

MicroRNAs (miRNAs) are small non-coding RNA molecules encoded by eukaryotic nuclear DNA, on average 22 nucleotides long, that function in transcriptional and post-transcriptional regulation of gene expression via base-pairing with complementary sequences within mRNA molecules, usually resulting in gene silencing via translational repression or target degradation.

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The Desired Sensation Level Multi-stage [i/o] Algorithm

Tech ID: TP-W-AD-005 Background The Desired Sensation Level: DSL [i/o] algorithm was released to manufacturers in the late 1990s in the form of a dynamic loadable/linked library (DLL). We appreciate your support and want you to know that the money that we have received from manufacturers in the form of license fees for the DLL

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