Technologies

Immune Classification of HPV-associated Head and Neck Cancer

Tech ID: L-21-011 Background HPV-driven (HPV+) head and neck squamous cell carcinoma (HNSCC) is the fastest rising cancer in North America. While cure rates can be high, around 20% of patients recur after primary treatment. Current multimodal treatment regimens are historically derived from clinical trials for the more aggressive HPV-negative HNSCC and may be more

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4D Computed Tomography Cardiovascular Flow Imaging

Tech ID: L-19-007 Background Computed Tomography (CT) is routinely used for anatomical assessment in patients with vascular and valvular diseases. Since blood flow assessment is also critical for optimizing the management of these patients, CT is often used in conjunction with other imaging tests for further disease evaluation, but this approach leads to ineffective clinical

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Fractional Flow Reserve Measurement with Dynamic Angiographic Computed Tomography

Background Coronary artery disease (CAD) is one of the leading causes of death in the world and is caused by the development of atherosclerotic plaques in the coronary arteries. Management of CAD patients depends on the functional significance of CAD. The clinical gold standard metric for assessing the functional significance of CAD is fractional flow

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Attenuation of Infection by Staphylococcus aureus

Tech ID: W-20-013 Summary Researchers at Western University have identified a compound that can inhibit the growth of Staphylococcus aureus, a deadly bacterium that can cause pneumonia and sepsis and is resistant to many antibiotics. Background In humans, Staphylococcus aureus may exist as a commensal bacterium or as a pathogen. Data from the United States

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HPV+ HNSCC Cell Lines

Tech ID: L-20-002 Background HPV+ HNSCC (head and neck squamous cell carcinoma) is increasing in occurrence in the HNSCC population around the world. Although there are numerous HPV negative HNSCC cell lines that have been established and that are used as models of HPV negative disease, there is a lack of HPV+ cell lines models

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Contrast-agent-free Medical Diagnostic Imaging

Tech ID: L-21-003 Background Contrast agent (CA) administration to a patient is a frequent prerequisite for medical imaging. For example, in heart imaging, the elimination of gadolinium contrast agent (CA) injections and manual segmentation are crucial for ischemic heart disease (IHD) diagnosis and treatment. In the clinic, CA-based late gadolinium enhancement (LGE) imaging and manual

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Rapid, Specific and Sensitive Point of Care Antibody Testing for SARS-CoV-2 (COVID-19)

Background As COVID-19 continues to rage on around the world, there is an urgent need for a simple, yet accurate antibody test to identify infected individuals in large scales to inform health decisions. Development of a rapid, accurate and specific point-of-care COVID-19 antibody test for use at community level remains an utmost priority. To date,

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Annexin and its Use to Treat Inflammatory Disorders

Sepsis is a complex clinical syndrome resulting from a harmful host immune response to infection characterized by the production of tumor necrosis factor-α (TNF-α), a pro-inflammatory cytokine, which has been shown to be one of the main mediators of cardiovascular dysfunction.

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Ghrelin Analogues as Molecular Imaging Probes

Human Growth Hormone Secretagogue Receptor (GHSR), a member of the G Protein-Coupled Receptors (GPCR) family, is mainly expressed in the hypothalamus, pituitary cells and a number of peripheral tissues.

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Schizophrenia Animal Model

Schizophrenia is a severely debilitating life-long disease with symptoms typically appearing in the early twenties, and consequently, it leaves a tremendous financial burden on patients and the society. Approximately 2.5 million Americans and 1% of the worldwide population (1 out of every 100 people) suffer from schizophrenia.

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