Technologies

Background With nearly 642 million people globally projected to live with diabetes in the year 2040, the risk for developing diabetes-related complications will drastically increase. Diabetes mellitus (DM) is a chronic degenerative metabolic disease that is characterized by sustained hyperglycemia. Hyperglycemia correlates with a number of DM-related complications and is one of the preeminent factors

Tech ID: W-22-021 Background In many settings across many industries, process performance is often only considered in terms of maximizing throughput over a given period. The primary consideration in creation of the output product tends to be functional workpieces that meet short term quality expectations. This approach neglects the consideration of long-term product integrity. In

Tech ID: L-21-011 Background HPV-driven (HPV+) head and neck squamous cell carcinoma (HNSCC) is the fastest rising cancer in North America. While cure rates can be high, around 20% of patients recur after primary treatment. Current multimodal treatment regimens are historically derived from clinical trials for the more aggressive HPV-negative HNSCC and may be more

Tech ID: L-19-007 Background Computed Tomography (CT) is routinely used for anatomical assessment in patients with vascular and valvular diseases. Since blood flow assessment is also critical for optimizing the management of these patients, CT is often used in conjunction with other imaging tests for further disease evaluation, but this approach leads to ineffective clinical

Background Coronary artery disease (CAD) is one of the leading causes of death in the world and is caused by the development of atherosclerotic plaques in the coronary arteries. Management of CAD patients depends on the functional significance of CAD. The clinical gold standard metric for assessing the functional significance of CAD is fractional flow

Tech ID: L-20-002 Background HPV+ HNSCC (head and neck squamous cell carcinoma) is increasing in occurrence in the HNSCC population around the world. Although there are numerous HPV negative HNSCC cell lines that have been established and that are used as models of HPV negative disease, there is a lack of HPV+ cell lines models

Tech ID: L-21-003 Background Contrast agent (CA) administration to a patient is a frequent prerequisite for medical imaging. For example, in heart imaging, the elimination of gadolinium contrast agent (CA) injections and manual segmentation are crucial for ischemic heart disease (IHD) diagnosis and treatment. In the clinic, CA-based late gadolinium enhancement (LGE) imaging and manual

Background As COVID-19 continues to rage on around the world, there is an urgent need for a simple, yet accurate antibody test to identify infected individuals in large scales to inform health decisions. Development of a rapid, accurate and specific point-of-care COVID-19 antibody test for use at community level remains an utmost priority. To date,

Sepsis is a complex clinical syndrome resulting from a harmful host immune response to infection characterized by the production of tumor necrosis factor-α (TNF-α), a pro-inflammatory cytokine, which has been shown to be one of the main mediators of cardiovascular dysfunction.

Schizophrenia is a severely debilitating life-long disease with symptoms typically appearing in the early twenties, and consequently, it leaves a tremendous financial burden on patients and the society. Approximately 2.5 million Americans and 1% of the worldwide population (1 out of every 100 people) suffer from schizophrenia.