Technologies

HPV+ HNSCC Cell Lines

Tech ID: L-20-002 Background HPV+ HNSCC (head and neck squamous cell carcinoma) is increasing in occurrence in the HNSCC population around the world. Although there are numerous HPV negative HNSCC cell lines that have been established and that are used as models of HPV negative disease, there is a lack of HPV+ cell lines models

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Contrast-agent-free Medical Diagnostic Imaging

Tech ID: L-21-003 Background Contrast agent (CA) administration to a patient is a frequent prerequisite for medical imaging. For example, in heart imaging, the elimination of gadolinium contrast agent (CA) injections and manual segmentation are crucial for ischemic heart disease (IHD) diagnosis and treatment. In the clinic, CA-based late gadolinium enhancement (LGE) imaging and manual

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4D Computed Tomography Cardiovascular Flow Imaging

Tech ID: L-19-007 Background Magnetic Resonance Imaging (MRI) is the non-invasive gold standard for blood flow assessment in larger blood vessels (arteries and veins), but MRI has limitations in terms of accessibility, patient throughput and operating cost. In contrast, Computed Tomography (CT) is one of the most frequently used diagnostic imaging modalities in hospitals, but

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Rapid, Specific and Sensitive Point of Care Antibody Testing for SARS-CoV-2 (COVID-19)

Background As COVID-19 continues to rage on around the world, there is an urgent need for a simple, yet accurate antibody test to identify infected individuals in large scales to inform health decisions. Development of a rapid, accurate and specific point-of-care COVID-19 antibody test for use at community level remains an utmost priority. To date,

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Portable Temperature Regulating Device for Medical and Temperature-Sensitive Products Packaging and Transportation

A portable temperature regulating device that could be integrated to either static cold storage (SCS) or perfusion devices for organs transportation.

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Annexin and its Use to Treat Inflammatory Disorders

Sepsis is a complex clinical syndrome resulting from a harmful host immune response to infection characterized by the production of tumor necrosis factor-α (TNF-α), a pro-inflammatory cytokine, which has been shown to be one of the main mediators of cardiovascular dysfunction.

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Ghrelin Analogues as Molecular Imaging Probes

Human Growth Hormone Secretagogue Receptor (GHSR), a member of the G Protein-Coupled Receptors (GPCR) family, is mainly expressed in the hypothalamus, pituitary cells and a number of peripheral tissues.

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Schizophrenia Animal Model

Schizophrenia is a severely debilitating life-long disease with symptoms typically appearing in the early twenties, and consequently, it leaves a tremendous financial burden on patients and the society. Approximately 2.5 million Americans and 1% of the worldwide population (1 out of every 100 people) suffer from schizophrenia.

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EGFR antagonist-mediated prevention of post myocardial infarction ruptures

Cardiovascular disease is a leading cause of death worldwide, claiming the lives of an estimated 17 million people annually. Myocardial infarctions (MI), or heart attacks, are a leading cause of mortality and morbidity. Complications following MI include maladaptive left ventricle (LV) tissue remodeling and cardiac rupture.

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Peptides targeting EGFL7, a critical player in angiogenesis

Epidermal growth factor-like 7 (EGFL7) is an endothelial cell secreted protein whose expression is restricted to actively remodeling vascular endothelium. It is critical for vascular tube formation during angiogenesis through localizing to the extracellular matrix (ECM) at the basal surface of endothelial cells and promoting endothelial cell adhesion. In adults, expression of EGFL7 is detected only at sites of active angiogenesis during wound repair, in the pregnant uterus and in tumors.

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